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KMID : 0382319910110020107
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Environmental Mutagens and Carcinogens
1991 Volume.11 No. 2 p.107 ~ p.117
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Effect of 3-Aminobenzamide on DNA Repair Synthesis and Chromosome Aberrations Induced by Mutagens in Synchronized Mammalian Cells
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Abstract
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The effect of 3-aminobenzamide (3AB), an inhibitor of poly (ADP-ribose) polymerase, on ethyl methanesulfonate (EMS)-or bleomycin (BLM)-induced DNA repair synthesis and chromosome aberrations was examined during the cell cycle of Chinese hamster ovary (CHO)-K1 cells. The synchronized cells were obtained by using thymidine double block method and mitotic selection method. Three assays were employed in this study unscheduled DNA synthesis, alkaline elution and chromosome aberrations. 3AB alone did not induce DNA repair and chromosome aberrations in all phases.
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KEYWORD
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